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Preoxygenation for Tracheal Aspirations in Intensive Care

RecruitingNAAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT06421012 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Clearing the airways is a complex phenomenon involving the production of secretions, the nature of mucus (viscosity, elasticity, stringiness, and adhesiveness), ciliary movement, and coughing. In intubated and ventilated patients, endotracheal suctioning occur when the patient is "unable to clear the airways of obstructions hindering the free passage of air." These suctioning can lead to transient desaturation exacerbated by a decrease in cardiac output due to increased mean arterial pressure, promoting cardiac arrhythmias. To minimize these effects, it is recommended to perform additional preoxygenation, by increasing the fraction of O2 in the air delivered to the patient by the ventilator 2-3 minutes before the procedure. These longstanding recommendations were reiterated in 2022, based on outdated studies involving systematic suctioning that required disconnecting the patient from the

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or older * Hospitalized in ICU, under invasive mechanical ventilation for less than 24 hours * Information and signature of consent by patient or relative/trusted person, or emergency inclusion procedure Exclusion Criteria: * Patient on ECMO * Not affiliated to a social security system * Pregnant * Under legal protection (curatorship, guardianship or safeguard of justice) * Patient under AME * Patient included in another interventional study that may have an impact on the evaluation criteria of the present study
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What it tests

  • Experimental : Patients without additional preoxygenation
  • Active Comparator : Patients with additional preoxygenation
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Where

1 site
Hôpital Pitié Salpêtrière
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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