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Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity

RecruitingNAAges 60 Years - 80 YearsAllFinis Terrae University
NCT06425042 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The prevalence of age-related chronic diseases (like obesity, type 2 diabetes and cardiovascular diseases) is mounting worldwide, reaching pandemic proportions. These age-related chronic diseases are associated with diminished skeletal muscle mitochondrial function in humans. Nicotinamide adenosine dinucleotide (NAD) is a coenzyme that regulates mitochondrial function, therefore, plays an important role in energy metabolism. Importantly, it has been shown that high cellular NAD+ levels as well as a high NAD+/NADH ratio promote metabolic and mitochondrial health. In contrast, NAD+ bioavailability declines upon aging in humans as well as in animal models of metabolic disorders and type 2 diabetes. These findings fuel the notion of boosting the NAD+ bioavailability in order to improve metabolic disturbances and mitochondrial dysfunction in aged individuals. Supplementation with nicotinamide

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participants are able to provide signed and dated written informed consent prior to any study specific procedures * Aged ≥ 60 and ≤ 80 years * Body mass index (BMI) 25 - 35 kg/m2 * Stable dietary habits (no weight loss or gain \> 5 kg in the past 3 months) * No signs of active cardiovascular disease, liver or kidney malfunction Exclusion Criteria: * Patients with congestive heart failure and and/or severe renal and or liver insufficiency * Uncontrolled hypertension * Any contra-indication for MRI scanning * Alcohol consumption of \> 3 servings per day for man and \>2 servings per day for woman * Smoking * Unstable body weight (weight gain or loss \> 5kg in the last 3 months) * Engagement in structured exercise activities \> 2 hours a week * Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results * Use of food supplements containing NR or Resveratrol (similar working mechanisms)
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What it tests

  • Nicotinamide Riboside (NR)
  • Placebo
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Where

1 site
Finis Terrae University
Santiago, Chile
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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