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Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

RecruitingNAAges 18 Years - anyAllVanderbilt University Medical Center
NCT06427538 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with complicated parapneumonic pleural effusion and empyema requiring chest tube placement as standard of care for inpatient management of their pleural space infection with or without intrapleural tissue plasminogen activator and deoxyribonuclease therapy * Age \> 18 years old. Exclusion Criteria: * Patients who have surgical tubes that can't accommodate a three-way stopcock. * Study subject has any disease or condition that interferes with the safe completion of the study. * Inability to provide informed consent. * Inability to undergo a chest X-ray. * If the managing clinician believes the chest tube will be placed for less than 24 hours. * Patients with an indwelling pleural catheter (IPC)
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What it tests

  • Saline Flush
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Where

5 sites
Henry Ford
Sterling Heights, United States
Creighton University
Omaha, United States
Mount Sinai
New York, United States
Vanderbilt University Medical Center
Nashville, United States
Virginia Commonwealth University
Richmond, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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