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Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel Disease

Recruitingn/aAges 35 Years - anyAllZhejiang Provincial People's Hospital
NCT06431711 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cerebral small-vessel disease (CSVD) is a significant contributor to stroke and dementia, primarily impacting individuals over the age of 60. Its prevalence exceeds 70% in the elderly population, imposing a substantial burden on brain health and the economy. Optical coherence tomography angiography (OCTA) is a new type of optical diagnostic imaging technology for non-invasive detection, which can perform multi-dimensional quantitative assessment of fundus retinopathy. Current studies have shown that fundus OCTA-derived parameters may have potential in characterizing imaging changes in CSVD. However, the correlation between retinal/choroidal parameters on OCTA and the CSVD imaging markers remains uncertain. FRESH-CSVD is a prospective, observational study that will use fundus OCTA-derived parameters to screen patients with CSVD, explore the relationship between relevant parameters based o

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Older than 35 years old; 2. Patients who underwent Multimodal MRI with any CSVD imaging marker; 3. Subjects who have signed informed consent. Exclusion Criteria: 1. Patient who was unable to cooperate with examinations; 2. There are known diseases that may cause or worsen CSVD (brain injury, Down syndrome, Alzheimer's disease, Parkinson's disease, etc.); 3. There are known eye diseases or severe underlying fundus lesions that may impact fundus assessment; 4. Suffering from serious systemic diseases, such as heart, liver, kidney diseases or major mental illnesses; 5. Contraindications for imaging examinations Exit Criteria: 1. Not meet the inclusion criteria. 2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator. 3. Any adverse or serious adverse events during the study period judged by investigator
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What it tests

  • Not listed
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Where

1 site
Zhejiang Provincial People's Hospital
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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