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Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases

RecruitingNAAges 1 Year - anyAllHospices Civils de Lyon
NCT06435468 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Rare diseases are defined as those that affect one person in 2,000, or around three million people in France. The majority of rare diseases are caused by genetics and tend to be severe when they begin in childhood. Autoimmune and autoinflammatory diseases, such as systemic lupus, juvenile dermatomyositis, and juvenile idiopathic arthritis, are examples of rare pediatric diseases. While autoimmune diseases are characterized by an inappropriate adaptive immune response, autoinflammatory diseases involve an excess of the innate immune response. The precise mechanisms of these diseases are not yet fully understood, but recent research has led to advances in their diagnosis and identification, particularly in early onset and familial forms. However, the rarity of these diseases and limited availability of biological samples pose significant challenges. This study aims to create a biological

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients * minor or adult patient of any age with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation, having started in childhood (\<18 years), or syndromic or familial * relative of a minor or adult patient with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation, having started in childhood (\<18 years of age) or syndromic or familial, * weight greater than 5 kg * Patient/parents/guardians who were informed of the study and signed the consent form. * patient affiliated to a social security scheme Healthy volunteer participants * minor or adult participants with no age restrictions * weight over 5 kg * Subject /Parents/guardians who were informed of the study and signed a consent form. * Patient affiliated to a social security scheme Exclusion Criteria: Patients \- Subjects /Parents/guardians, refusing to participate in the study Healthy volunteer participants : * active infection (viral, bacterial, parasitic) * history of neoplasia (\< 5 years) or current neoplasia * participants with a personal or family history of autoimmune disease * immunocompromised participant (immune deficiency or transplant recipient) * Subjects/parents/guardians refusing to participate in the study * Adults under legal protection (guardianship, curatorship)
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What it tests

  • Blood sample for genetic analysis
  • Blood sample for immunological response assessments
  • Blood sample to identify relevant biomarker of the disease
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Where

13 sites
Service de rhumatologie pédiatrique Hôpital Femme-Mère-enfant
Bron, France
Hôpital Jeanne de Flandre (CHU de Lille)
Lille, France
Hôpital Claude Huriez (CHU de Lille)
Lille, France
Hôpital Archet 2
Nice, France
Hôpital Necker-Enfants Malades (AP-HP)
Paris, France
Hôpital Robert Debré (AP-HP)
Paris, France
Hôpital Kremlin-Bicêtre (AP-HP)
Paris, France
Hôpital Nord (CHU ST-Etienne)
Saint-Etienne, France

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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