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A Pilot Study of Genetic Testing Uptake Through Enhanced Oncology Nurse-Led Intervention

RecruitingNAAges 18 Years - anyAllUniversity of California, Davis
NCT06436157 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Genetic factors are a significant determinant of the likelihood of developing various types of cancers. Identification of germline risk can have important implications for both patients and their families. Although estimates vary, pathogenic germline variants can be seen in \~3-17.5% of unselected patients with cancer with important clinical significance. Unfortunately, despite progress in multigene testing and the identification of heritable conditions, genetic counseling and testing (GCT) remains underutilized among cancer patients. Although there are multiple barriers to low testing, initial referral to GCT from the treating oncologist has been noted to be the most significant barrier. Nurse navigation has been shown to improve the timeliness of cancer care and patient outcomes across various cancer types and improve the uptake of genomic testing in cancer patients. Despite proven be

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults (≥ 18 years) * Diagnosed with a solid tumor cancer type that has established guidelines suggesting the utility of genetic testing in treatment (breast, ovarian, prostate, pancreatic, colon, Lynch syndrome-related cancers (colorectal, endometrial, gastric, ovarian, pancreatic, urothelial, brain (usually glioblastoma), biliary tract, small intestine), Li-Fraumeni syndrome tumor spectrum (e.g., soft tissue sarcoma, osteosarcoma, central nervous system tumors, breast cancer, adrenocortical carcinoma), etc.) * Eligible for GCT based on the current NCCN guidelines * Starting new systemic therapy or switching systemic therapy * Eligible for GCT as per the current NCCN guidelines * No prior genetic testing (or tested before 2014) Exclusion Criteria: * Prior GCT with test results available (if tested 2014 onwards) * Patients scheduled for treatment education with Advanced Practice Provider (typically reserved for more complex regimens) * Patients with cognitive impairments or severe psychological disorders that would limit their ability to understand the genetic counseling/testing information or give informed consent. * Any other condition that would, in the investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures (e.g., patients requiring urgent therapy and/or inpatient chemotherapy initiation). * Patients who are currently participating in other clinical trials that could confound the outcomes of genetic testing uptake. * Prospective participants who, in the investigator's opinion, may not be able to comply with all study procedures (including compliance issues related to logistics). * Hematologic malignancy
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What it tests

  • Enhanced education
  • Usual care education
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Where

2 sites
Enloe Regional Cancer Center
Chico, United States
University of California, Davis
Sacramento, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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