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The Efficiency and Safety of PRP Treatment After Anterior Cruciate Ligament Reconstruction.

RecruitingNAAges 18 Years - 45 YearsAllNicolaus Copernicus University in Toruń, Collegiu…
NCT06442319 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The anterior cruciate ligament (ACL) is the main stabilizer of the knee joint, as it controls anteroposterior and rotatory knee laxity. The number of ACL injuries has increased in the past three decades because more and more people participate in recreational and competitive sporting activities. Injury to the ACL often leads to functional instability, damage to the meniscus and articular cartilage, and an increased risk for osteoarthritis (OA). Emphasizes the fact that ACL has limited healing potential 'The gold standard' treatment is ACL reconstruction, with over 200,000 reconstruction surgeries performed annually in the United States. However, despite the success of surgery in restoring functional stability, it has been found so far in several studies that the prevalence of moderate to severe arthritis in long-term radiographic follow-up is more than 50% after ACL reconstruction within

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📋 Eligibility rules (as published)
Inclusion Criteria: * subject is 18-45 years old * subject has BMI \< 40 kg/m2 * subject had ACL reconstrution * small asymptomatic meniscal lesions that won't require repair * subject must be willing to abstain from other intra-articular treatments of the knee for the duration of the study. * subject is willing to discontinue all analgesics including nonsteroidal anti-inflammatory drugs (NSAIDs), except tramadol and paracetamol, at least one month before the synovial fluid aspiration and through the completion of the study * subject is able to understand and comply with the requirements of the study and voluntarily provides consent Exclusion Criteria: * subject has a history of metabolic diseases, endocrine disorders, rheumatic and connective tissue diseases, cancer, hormonal contraception, steroid therapy, antibiotic therapy * subject had an intraarticular injection into the affected joint * subject had previous operations (beside ACL reconstruction) or fractures of the affected limb * subject has a history of nicotine, alcohol, or drug addiction * subject has a meniscal tear that requires suturing or total meniscectomy seen on MRI * subject has multi-ligament knee injuries or multi-organ injury * subject has significant varus or valgus deformity greater than 10 degrees in either knee, determined by an X-ray
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What it tests

  • Platelet-rich plasma
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Where

1 site
Dawid Szwedowski
Torun, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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