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Role of Endothelial Function in SCI CVD Risk

Recruitingn/aAges 18 Years - 89 YearsAllCraig Hospital
NCT06443151 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear. Doctors generally attributed the increased risk with weight gain and developing diabetes, but many studies have shown that even without these common factors, plaque in vessels is developing more often and faster. Endothelial cells are a single layer of cells that line all vessels in the body and plays an important role in vessel health. Damage to endothelial cells is known to lead to heart attacks and strokes. Past studies on endothelial cells of people with spinal cord injury have been unclear. The investigators have new data that these cells are unhealthy after spinal cord injury a measurement. This includes measuring endothelial health by directly altering its function usin

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women of all races, ethnic backgrounds\>18 years of age * Traumatic spinal cord injury (Sports, Assault, Transport, Fall, Other Traumatic Causes) * Time since injury (\> 12 months) * Paraplegia Motor Complete Injury (neurological level of injury at T2 or below, ASIA Impairment Scale A or B Exclusion Criteria: * History of high blood pressure * History cardiovascular disease (coronary artery disease, congestive heart failure, myocardial infarction, cerebrovascular accident). * History high cholesterol * History of Diabetes Type I or Type II * History of Obstructive Pulmonary Disease * History of Chronic Kidney or Liver Disease * History of Cancer * History of Autoimmune Disease (Thyroid Disease, Lupus, Rheumatoid Arthritis, etc). * History of smoking tobacco in the last 12 months * History of alcohol use
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What it tests

  • Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid)
  • venous occlusion plethysmography
  • Acetylcholine
  • Sodium Nitroprusside
  • Ascorbic acid
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Where

1 site
Craig Hospital
Englewood, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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