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An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma

RecruitingPhase 2Ages 18 Years - anyAllMayo Clinic
NCT06444412 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This clinical trial evaluates whether gallium-68 (Ga-68) prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) imaging is useful in differentiating between disease that has come back after a period of improvement (recurrence) or that is growing, spreading, or getting worse (progression) and treatment effect in patients with glioma. Patients with glioma undergo frequent imaging for assessment of disease status. After first-line treatment however, the correlation between imaging findings and tumor activity can be confused, and surgery is often required for definitive diagnosis. The PET/CT scanner is an imaging machine that combines 2 types of imaging in a single scan. The PET scanner detects and takes pictures of where the radioactive imaging agent (68Ga PSMA-11) has gone in the body and the CT scanner uses x-rays to take structural pictur

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years. * History of World Health Organization (WHO) grade III or IV infiltrating glioma previously treated with first-line chemoradiotherapy. * MRI findings compatible with contrast-enhancing recurrent infiltrating glioma. * Planned biopsy or resection of suspected disease recurrence. * Willing to sign release of information for any radiation and/or follow-up records. * Ability to provide informed written consent. * Ability to provide tissue for mandatory correlative research component. Exclusion Criteria: * Unable to undergo a PSMA PET/CT scan (e.g. body habitus, claustrophobia). * Any of the following: * Pregnant women * Nursing women * Men or women of childbearing potential unwilling to employ adequate contraception
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What it tests

  • Computed Tomography
  • Electronic Health Record Review
  • Ga 68 PSMA-11
  • Positron Emission Tomography
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Where

1 site
Mayo Clinic in Rochester
Rochester, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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