Trial of Precision Medicine in Emergency Departments

Inclusion Criteria: 1. Adults 40 years or older presenting to a participating ED 2. Receipt of a new order/prescription for a selected PGx medication (Appendix 1), with a duration greater than 7 days, during the current ED visit or within 30 days prior. 3. Documentation of at least 2 prior ED or urgent care visits within the past 12 months Exclusion Criteria: 1. Prior clinical pharmacogenetic test results within the EHR for genes relevant for this study (Appendix 1). 2. History of hepatic or renal transplant 3. History of severe liver disease (stage Child-Pugh C) or renal disease eGFR \<15 ml/min. 4. Any medical condition that would prohibit the ability to complete the study 5. Prisoners, wards of the state, or patients being held under the Baker Act or Marchman Act 6. Life expectancy less than 6 months