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Resistant Hypertension An Open, Complicated ("Cum Plicare") or Complex ("Cum Plexus") Syndrome?

Recruitingn/aAges 18 Years - 85 YearsAllUniversity of Campinas, Brazil
NCT06450327 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Resistant arterial hypertension (RAH) is a complex and multifactorial syndrome, with hyperactivity of the sympathetic nervous system (SNS) and reduction of vagal activity being considered some of the main causes of refractoriness to treatment. Seen from the outside, it resembles a complicated (see lat. "Cum plicate") or complex disease (see lat. "Cum plexus"), Chaotic with the participation of several open systems. For example, in recent years some relationships have been demonstrated between the autonomic nervous systems, synaptic mediators, hormones, inflammatory and immune responses. However, these findings have not been investigated together and systematically. In the present project, we intend to establish and compare, in an integrated way, the clinical alterations present in RAH (resistant and refractory), hemodynamic variables, autonomous activity (sympathetic and baroreflex) and

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📋 Eligibility rules (as published)
Inclusion Criteria: * men and women over 35 years of age diagnosed with resistant arterial hypertension (RH), in accordance with the latest international and national guidelines; * be able to understand, verbalize and answer questions; * agree to participate in the study and sign the Informed Consent Form; * after clearly understanding it; * be under regular follow-up at the UNICAMP Cardiovascular Pharmacology outpatient clinic for at least six months; * have proven adherence to non-pharmacological and pharmacological treatment; * women in the reproductive phase must be using a proven effective contraceptive method. Exclusion Criteria: * clinical history or clinical symptoms of heart failure; * patients with dilated cardiomyopathies, valvular heart disease, pericardial disorders; * patients with cerebrovascular disease or peripheral arterial disease, nephropathies, liver diseases, smoking, autoimmune diseases and use of illicit substances; * any abnormal condition that may interfere with the results of the study or the health of the volunteer, as judged by the researcher; * women who are pregnant or intend to become pregnant; * current participation in another investigative study; * major depression or other relevant psychiatric disorders.
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What it tests

  • This is a cross-sectional observational study
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Where

1 site
Tatiane de Azevedo Rubio
Votuporanga, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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