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Hemodynamic Management Following Acute Traumatic Spinal Cord Injury

RecruitingNAAges 18 Years - anyAllThe University of Texas Health Science Center, Ho…
NCT06451133 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Traumatic spinal cord injury Exclusion Criteria: * Patients with an injury from a trauma that penetrates the spinal cord (i.e., gunshot or knife wound resulting in cord transection) * Preexisting neurologic or spinal cord injury * Severe traumatic brain injury as measured by a best resuscitated Glasgow Coma Scale (GCS) score of \<8 at 24 hours following injury * Presence of traumatic injuries that preclude spine surgery within 24 hours of presentation * Concomitant injury/illness requiring targeted blood pressure management (e.g., injury to the aorta, aortic dissection, hemorrhagic stroke) * Preexisting history of neuromotor disorders (i.e., cerebral palsy, Parkinson disease, etc.) * Not expected to survive \>24h * Cord transection identified by radiologist and agreed upon by the spine surgery team * Injury below spinal cord level L1 * Prisoners * Pregnant women
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What it tests

  • Mean arterial blood pressure (MAP) goal of ≥65 mmHg
  • Mean arterial blood pressure (MAP) goal of 85-90 mmHg
  • Spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg
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Where

1 site
The University of Texas Health Science Center at Houston
Houston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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