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Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

RecruitingPhase 1Ages 18 Years - 70 YearsAllVerve Therapeutics, Inc.
NCT06451770 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

VT-20101 is an Open-label, Phase 1b, Single-ascending dose study that will evaluate the safety of VERVE-201 administered to patients with Refractory Hyperlipidemia. VERVE-201 uses base-editing technology designed to inactivate the expression of the ANGPTL3 gene in the liver and lower circulating low-density lipoprotein cholesterol (LDL-C) and triglycerides. This study is designed to determine the safety and pharmacodynamic profile of VERVE-201 in this patient population.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Refractory hypercholesterolemia * Refractory hypertriglyceridemia Exclusion Criteria: * Active or history of chronic liver disease * Current treatment with monoclonal antibody targeting ANGPTL3 or prior treatment within specified timeframe * Clinically significant or abnormal laboratory values as defined by the protocol
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What it tests

  • VERVE-201
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Where

18 sites
Clinical Study Center
Garden Grove, United States
Clinical Study Center
Clearwater, United States
Clinical Study Center
Miami Lakes, United States
Clinical Study Center
Port Orange, United States
Clinical Study Center
New York, United States
Clinical Study Center
Adelaide, Australia
Clinical Study Center
Melbourne, Australia
Clinical Study Center
Chicoutimi, Canada

…and 10 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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