Prednisone for CRPS in Distal Radius Fracture

Inclusion Criteria: 1. Patient is aged 19 years or older; 2. Patient has a unilateral, closed, distal radius fracture confirmed by radiographs; 3. The fracture is acute, within 21 days of injury; 4. Patient undergoes open reduction internal fixation with volar locking plate; 5. Patient is identified as at risk of developing CRPS with 2 or more of the following: 1. Pain score on visual analogue scale (VAS) greater than or equal to 5/10 within 1 week of injury and beyond; 2. Centre of Epidemiologic Studies Depression (CES-D) score on presentation is greater than or equal to 16; 3. Patient identifies as female; 6. Patient is identified as developing signs of CRPS based on the Budapest CRPS Criteria; 7. Patient provides informed consent. Exclusion Criteria: 1. Patient has previously fractured ipsilateral wrist; 2. Patient has neurovascular injury associated with distal radius fracture; 3. Patient has associated extremity or polytrauma injuries that would interfere with rehabilitation and outcome measurements, in the opinion of the investigator; 4. Patient has allergy to prednisone or placebo ingredients; 5. Patient has contraindication to prednisone or placebo ingredients; 6. Patient already takes a glucocorticoid medication; 7. Patient has active bacterial, viral, or fungal infection; 8. Patient is diagnosed with diabetes; 9. Patient is pregnant, planning on becoming pregnant, or breastfeeding; 10. Patient is anticipated to have difficulty completing study follow up, in the opinion of the investigator.