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Invasive Candidiasis in Critical Care

Recruitingn/aAges 12 Months - anyAllUniversity Hospital Ostrava
NCT06456151 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The combination of acute phase marker monitoring and the "T2Candida" assay (name of the test) will represent an acceleration of the identification of the causative agent of mycotic infection, a significant improvement in the specificity and positive predictive value of this strategy in the diagnosis of invasive candidiasis and candidemia in ICU patients, thereby improving the clinical condition of patients and reducing the cost of specific antifungal therapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * critically ill patients * new onset sepsis * rise in body temperature \>38°C according to The Third Consensus Definitions for Sepsis and Septic Shock * colonization with Candida spp. from more than 1 non-sterile site * body temperature \>38 °C despite 5 days of broad-spectrum antibiotic therapy with the presence of at least 1 of the following risk factors: abdominal surgery, secondary peritonitis, pancreatitis, central venous catheter (CVC) insertion, total parenteral nutrition (CPV), dialysis, steroid therapy, immunosuppressive therapy, or liver transplantation * microbiological test results will be reviewed and categorized based on whether Candida sp. is isolated from at least 2 non-sterile sites (±3 days) and whether there is an alternative microbiological diagnosis. Exclusion Criteria: * not signing the informed consent with participation in the study * administration of antifungal therapy prior to collection of the biological material required for the study
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What it tests

  • Invasive candidiasis test
  • Urine sample collection for future research
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Where

2 sites
University Hospital Ostrava
Ostrava, Czechia
University Hospital Motol
Prague, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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