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MRSI Evaluation for Minor Stroke With Large Vessel Occlusion

Recruitingn/aAges 18 Years - 100 YearsAllShanghai 6th People's Hospital
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to understand acute anterior circulation large artery occluded minor stroke (LVO-MIS) evolution using magnetic resonance spectroscopic imaging evaluation. The main questions it aims to answer are: 1. Neurometabolic predictors of early neurological deterioration and functional outcome; 2. Temporal and spatial dynamic changes of the neurometabolites from the acute stage (within 24 hours), through the subacute stage (5-7 days), to the chronic stage (90 days); 3. Temporal and spatial dynamic changes of the neurotransmitters GABA, glutamate, and glutamine from the acute stage to the chronic stage; 4. Brain regions exhibiting changes in whole-brain metabolic network connectivity.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Adult (age โ‰ฅ 18 years) patients presenting with symptoms consistent with acute ischemic stroke due to occlusion of the intracranial internal carotid artery and/or M1 or M2 segment of the middle cerebral artery; 2. Patients with mild symptoms at admission (National Institutes of Health Stroke Scale (NIHSS)\<6); 3. Baseline multimodal-CT imaging, including NCCT, CTA and CTP, performed at the trial-site hospital; 4. Time from symptom onset or last known normal to enrollment is less than 24 hours; 5. Patient or legal representative willing to comply with protocol requirements and data collection procedures, understand and sign informed consent. Exclusion Criteria: 1. A pre-incident mRS โ‰ฅ 1 point before onset; 2. Previous clear history of cerebral infarction, cerebral hemorrhage, brain tumor and other diseases that affect cerebral metabolism; 3. Intolerance or non-cooperation with magnetic resonance examination; 4. Severe cardiac, hepatic, renal impairment or other systemic serious advanced diseases; 5. Pregnancy or lactation; 6. Life expectancy is less than 3 months; 7. Other conditions that, in the opinion of the investigator, are not suitable for participation in this study or may pose a significant risk to the patient (such as inability to understand and/or comply with study procedures and/or follow-up due to psychiatric disorders, cognitive or emotional disorders).
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What it tests

  • Magnetic resonance spectroscopic imaging
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Where

1 site
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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