🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic

Recruitingn/aAges 18 Years - anyAllUniversity of Bonn
NCT06460142 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR). This longitudinal study aims to dissect the complex immunological landscape and systemic manifestations of these conditions through a combination of diagnostic imaging and detailed immunological profiling. The study focuses on three primary objectives: (1) Identifying and analyzing cytokine profiles and immune cell phenotypes, employing techniques like flow cytometry, enzyme-linked immunosorbent assays (ELISA), and next-generation sequencing to predict disease activity and therapeutic responses. (2) Advancing diagnostic and monitoring capabilities through the application of novel and established imaging technologies, including MRI, optical coherence tomography angiography (O

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Informed Consent: Participants (\>18 years) must provide written informed consent to voluntarily participate in the study. * Confirmed Diagnosis: Diagnosis of GCA or PMR confirmed by the treating physician and fulfilling expanded ACR-EULAR classification criteria. Patients must have been either newly diagnosed within the last three days or have experienced a disease flare within the same timeframe. Exclusion Criteria: * Severe Renal Insufficiency: Chronic glomerular filtration rate (GFR) less than 30 mL/min. * Other Medical Conditions Requiring Glucocorticoids: Presence of medical conditions other than GCA or PMR that necessitate continuous or intermittent treatment with oral or parenteral glucocorticoids. * Other Inflammatory Rheumatic Diseases: Patients with other inflammatory rheumatic diseases.
💊

What it tests

  • Aortic/ cardiac magnetic resonance imaging
  • Vascular ultrasound
  • Transorbital Ultrasound
  • Contrast-Enhanced Ultrasound
  • Optical coherence tomography angiography
📍

Where

1 site
University Hospital Bonn
Bonn, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy