Proton Therapy for Locally Advanced Cervical Cancer

Inclusion Criteria: * Inclusion criteria: * Cancer of the uterine cervix considered suitable for curative treatment with definitive radio- (chemo) therapy including IGABT * Positive biopsy showing squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix. * Staging according to Intenational federation of Gynecology and Obstetrics (FIGO) and TNM guidelines * T1-3N1M0 (FIGO stage IIIC1 (with ≥3 pelvic lymph node metastases) and IIIC2) * Para-aortic metastatic nodes below L1-L2 are allowed (FIGO stage IVB) * Magnetic Resonance Imaging (MRI) and Positron Emission Tomogaraphy-computerized Tomograpy (PET-CT) of the retroperitoneal space and abdomen at diagnosis * Patient written, informed consent * Age≥18 years * Patients must be able to understand a Danish or Swedish Exclusion Criteria: * Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin * Metastatic disease beyond para-aortic region (L1-L2 interspace) * Previous pelvic or abdominal radiotherapy * Combination of preoperative radiotherapy with surgery * Patients receiving neoadjuvant chemotherapy * Contra indications to MRI * Contra indications to IGABT * Contra indications to protontherapy * Small cell histology (neuroendocrine tumors) * Active infection or severe medical condition endangering treatment delivery * Pregnant, lactating or childbearing potential without adequate contraception * Human Immune Deficiency Virus (HIV) * Patients with no possibility of follow up