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Neutrophil Extracellular Traps in Different Forms of Systemic Sclerosis

Recruitingn/aAges 18 Years - anyAllCHU de Reims
NCT06462768 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Systemic SClerosis (SSC) is a systemic disease characterized by limited or diffuse cutaneous sclerosis, microangiopathy, overproduction of autoantibodies and variable organ damage due to vasculopathy and/or fibrosis. The loss of self-tolerance is believed to be caused by the dysregulation of both innate and adaptive immune systems and may involve Reactive Oxygen Species (ROS). Neutrophils are potent producers of ROS and may play a role in endothelial cells and fibrobasts dysfunction, as in autoantibodies generation. However, their role in SSC pathogenesis remains to be determined. Recent studies discovered abnormal regulation of Neutrophil Extracellular Traps (NETs) in other auto-immune diseases such as Systemic Lupus Erythematosus (SLE). NETs are web-like structures composed of chromatin backbones and granular molecules. They are released by activated neutrophils through a process call

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📋 Eligibility rules (as published)
Inclusion Criteria: \*For patients of group 1: * Patients with systemic sclerosis (ACR-EULAR Criteria) * Patients taking care of in internal medicine or in dermatology department's of the university hospital of Reims * Patients consenting to participate to the study * Patients enrolled in the national healthcare insurance program For patients of group 2: * Patients with other connective tissue disease (ACR specific-disease criteria) * Patients taking care of in internal medicine or in dermatology department's of the university hospital of Reims * Patients consenting to participate to the study * Patients enrolled in the national healthcare insurance program For patients of group 3 (healthy volunteers) * Patients eligible for blood donation (blood donation regulation criteria of January 11th 2022 decree) * Patients without medical history of autoimmune systemic or chronic inflammatory systemic disease, * Patients without current or past neoplasy disease, * Patients without chronic metabolic pathology * Patients without treatment by anti inflammatory or corticotherapy for the last 15 days, * Patients without infectious pathology or inflammatory acute for the last 15 days * Patients consenting to participate to the study Exclusion Criteria for patients of all groups: * Patients/Healthy volunteers under 18 years old * Patients/Healthy volunteers protected by the law * Patients/Healthy volunteers not consenting to participate to the study after information * Patients with inflammatory pathology or infectious acute intercurrent pathology in the last 15 days before inclusion * Pregnant or breastfeeding women
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What it tests

  • Blood sample
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Where

1 site
Chu Reims
Reims, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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