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Investigating aCute heArt failuRe Decongestion Guided by Lung UltraSonography

RecruitingNAAges 18 Years - anyAllAntonio Leidi
NCT06465498 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to investigate whether a lung ultrasonography (LUS)-guided decongestion strategy in adults hospitalized for acute heart failure (AHF) can improve patient-centered outcomes. The main questions it aims to answer are: * Does this strategy shorten the length of stay and reduce early hospital readmissions? * Does this strategy improve patients' symptoms and quality of life ? Researchers will compare LUS to physical examination (PE).

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≥ 18 years old * Planned or actual admission to intermediate care units, general internal medical or cardiology wards * Diagnosis of congestive AHF on admission chart (primary or secondary diagnosis) * Raised value of N terminal-pro-brain natriuretic peptide (≥1000 ng/l). Key Exclusion Criteria: * Known isolated right heart failure * Systolic blood pressure \<90 mmHg, mean arterial pressure \<65 mmHg at the moment of inclusion * The following conditions mimicking lung cardiogenic oedema on LUS if known at inclusion and documented: Interstitial lung disease, lung cancer or metastasis, acute respiratory distress syndrome, pulmonary contusion * Known virologically confirmed SARS-CoV-2 pneumonia in the preceding 3 months * Unwillingness to give consent * Subjects who are pregnant or breastfeeding * Hospitalisation for palliative care and probable end-life within 30 days
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What it tests

  • LUS decongestive strategy
  • PE decongestive strategy
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Where

5 sites
Trois-Chêne Hospital, Geneva Univesity Hospitals
Geneva, Switzerland
Geneva University Hospitals
Geneva, Switzerland
Inselspital, Universitätspital
Bern, Switzerland
Fribourg University Hospital
Fribourg, Switzerland
Ospedale Civico, Ente Ospedaliero Cantonale
Lugano, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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