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Low Voltage Electrical Stimulation for Depression in Parkinson's Patients

RecruitingNAAges 19 Years - 65 YearsAllUniversity of South Alabama
NCT06467695 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD). The main questions it aims to answer are: 1) Can the use of mgTDCS significantly improve the self-reported level of depression and apathy in patients with PD from pre-intervention to post-intervention compared to a sham control? 2) Can the use of mgTDCS significantly normalize the cortical eeg alpha asymmetry so commonly seen in depressed patients compared to sham mgTDCS? 3) Can the use of mgTDCS significantly improve scores on neuropsychological tests of working memory?

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📋 Eligibility rules (as published)
Inclusion Criteria: * 19 to 65 years in age. * Parkinson's Group must have a physician dx of Parkinson's Disease * Must meet exhibit elevated levels of depression on the Beck Depression Inventory (scores of 20 or above). * Must be willing and able to travel of the Psychology Department for EEG and tDCS sessions. * Participants who have undergone surgery for Deep Brain Stimulation implantation may be enrolled if advised to and monitored by their physician. * Read and understand spoken English. Exclusion Criteria: * No history of or being treated for epilepsy or other seizure disorders. * No history of penetrating head wounds or TBI greater than mild TBI. * No history of atypical Parkinson's
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What it tests

  • BIOPAC Stimsola
  • BIOPAC Stimsola Sham (zero amps)
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Where

1 site
University of South Alabama
Mobile, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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