Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial

Inclusion Criteria: * Age between 18 and 75 years; * sABI due to traumatic, vascular, anoxic, or mixed etiology; * Stable behavioral/cognitive diagnosis on at least 4 behavioral evaluations in 1 week using the Italian version of the CRS-R in patients with pDoC, or the LCF-based cognitive assessment in patients with eDoC; * Time post-injury between 28 days and 6 months \[1\]; * Not recovered upright station; * Written informed consent by the patient's legal rep-resentative/primary caregiver. Exclusion Criteria: * Severe medical conditions hampering verticalization (e.g., severe hypotension or conditions realizing hemodynamic instability, end stage or severe symptomatic heart failure with reduced ejection fraction, cardiac arrhythmia of new diagnosis or arrhythmic flare, severe hepatic failure, chronic severe lower limb arterio-venous disease, sep-sis/septic shock, thrombus venous embolism of new diag-nosis, severe autonomic dysreflexia); * Severe medical conditions hampering lower limb mobili-zation (e.g., fractures, heterotopic ossifications); * Severe medical conditions impacting EEG activity (e.g., sub-continuous or abundant EEG epileptiform abnormali-ties); * Severe medical conditions influencing conscious-ness/cognitive status, such as severe hyponatremia or hy-poglycemia; * Contraindications to the use of Erigo®Basic and/or Eri-go®Pro (Hocoma, Volketswil, Switzerland) as per technical data sheet (see Appendix A); * Presence of prohibited drugs