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Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT06472934 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Informed Consent must be signed by the subject prior to any study intervention. * Adult patients (\> 18 years) with severe symptomatic aortic stenosis eligible and scheduled for elective TAVR and are able to give consentand are able to give consent * Indication for B-blocker therapy with a prior treatment duration of at least 1 month before inclusion. Exclusion Criteria: * Emergency or urgent indication for TAVR. * Hemodynamically unstable patients receiving inotropic medication. * Prior permanent pacemaker implantation. * Existing indication for pacemaker implantation. * Hemodynamic relevant left ventricular outflow tract obstruction. * Prior intolerance of B-blocker medication. * Life expectancy \< 1 year. * Known or suspected non-compliance, drug, or alcohol abuse. * Inability to give consent, or follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant. * Being in a dependent relationship with the trial site * Participation in another study with investigational drug within the 30 days preceding and during the present study. * Previous enrolment into the current study. * Pregnancy or breast feeding women
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What it tests

  • Transcatheter aortic valve replacement in the absence of B-blocker treatment
  • Transcatheter aortic valve replacement
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Where

11 sites
Medical University of Graz
Graz, Austria
University Hospital Salzburg
Salzburg, Austria
University Medical Center Freiburg
Bad Krozingen, Germany
Kerckhoff-Klinik GmbH
Bad Nauheim, Germany
Herz- und Diabeteszentrum NRW Universitätsklinik
Bad Oeynhausen, Germany
Universitätsklinikum Giessen und Marburg GmbH
Giessen, Germany
Universitätsklinikum Schleswig-Holstein AöR
Kiel, Germany
University Hospital Basel
Basel, Switzerland

…and 3 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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