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Comparison of Serum Myokine Dosages and Imaging Methods in the Evaluation of Sarcopenia in Patients With Hepatocellular Carcinoma

RecruitingNAAges 18 Years - anyAllCHU de Reims
NCT06475118 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

It is known that some substances present in the blood, called 'myokines,' influence muscle loss. Some may accelerate this loss, while others may prevent it. Inflammatory substances in the blood can also contribute to muscle loss. Sarcopenia is assessed by an imaging technique called 'Skeletal Muscle Mass Index (SMI)' to measure muscle mass. This analysis can be done from radiological examinations. Sarcopenia has a serious impact on patients with hepatocellular carcinoma. It increases the risk of death, cancer recurrence, and decreases the response to treatments. Therefore, the investigators want to determine if blood tests for myokines obtained by simple blood draw can improve the assessment of sarcopenia in this specific setting.

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📋 Eligibility rules (as published)
Inclusion criteria: * New diagnosis of HCC made by radiology and/or histopathology according to EASL criteria, regardless of the degree of hepatic fibrosis (METAVIR F0-F4) * Availability of a pre-therapeutic three-phase contrast-enhanced abdominal-pelvic CT scan. Non-inclusion criteria: * Presence of an active cancer other than HCC * Uncontrolled HIV infection.
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What it tests

  • Dynamometry measurement, myokine dosing, sarcopenia calculation
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Where

1 site
Damien JOLLY
Reims, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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