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Modeling Host-Pathogen Interaction Using Lymphoid Organoids

Recruitingn/aAges 2 Years - 120 YearsAllNational Institute of Allergy and Infectious Dise…
NCT06479837 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Staphylococcus aureus (S.aureus) are bacteria that can make people sick. Sometimes, an S. aureus infection can develop inside the spine; these infections can lead to paralysis and death. Researchers do not know how S. aureus interacts with a person s cells to cause infections in the spine. Objective: To learn how S. aureus interacts with cells in the body using tissues from tonsils discarded after standard surgery to remove them. Eligibility: People aged 2 years and older who are scheduled to have their tonsils removed. Design: Researchers will select participants for the study based on review of their existing medical records, including results of blood tests; any imaging scans, including x-rays; and reports about tissue specimens. Participants will answer questionnaires about their health and past infections. They can do this online or on paper. Participants will c

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📋 Eligibility rules (as published)
* INCLUSION CRITERIA: To be eligible to participate in this study, an individual must meet all of the following criteria: * Aged \>=2 yrs. * Undergoing tonsillectomy as part of their clinical care. * Able to provide informed consent (for ages \>=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 yrs). * Willing to allow samples and data to be stored and shared for future secondary research. * Willing to allow future genetic testing on their biospecimens. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Active infection. * Active tonsilitis. * Pregnant. * Diagnosed with an immunosuppressive condition or currently taking immunosuppressive medications. * Current or past intravenous drug use. * Any condition that, in the judgment of the investigator, may put the participant at undue risk or make them unsuitable for participation in the study
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What it tests

  • Not listed
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Where

2 sites
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, United States
National Institutes of Health Clinical Center
Bethesda, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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