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Prospective, Longitudinal Biocollection in Thoracic Oncology, Including Newly Diagnosed Lung Cancer Patients

RecruitingNAAges 18 Years - anyAllNantes University Hospital
NCT06481813 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In clinical trials, patients are selected according to strict eligibility criteria (inclusion and exclusion criteria). These criteria aim to ensure homogeneity within the trial population, but may omit patients with specific characteristics, comorbidities or co-medications. Indeed, patients of advanced age, with comorbidities or brain metastases, who are frequently encountered in clinical practice, are often excluded from clinical trials. Real-life data in oncology play a vital role in assessing the efficacy of therapies and therapeutic strategies, complementing data from controlled clinical trials. They make it possible to analyze a larger population and take into account multiple variables such as patient history, co-medications and comorbidities, but also to analyze efficacy and toxicity data in populations not represented in clinical trials. The establishment of a prospective cohort

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients : * Adult * Patient newly diagnosed with NSCLC or CPC * Cared for at Nantes University Hospital * Affiliated or beneficiaries of a social security scheme or similar * Treated with a systemic therapy including chemotherapy and/or immunotherapy and/or targeted therapy and/or therapy as part of a clinical trial after agreement from the sponsors of the studies concerned (only in the absence of blinding). * Having agreed to participate in this study by signing the biocollection consent. Healthy subjects : * Adult * Affiliated or beneficiaries of a social security or similar scheme * Who have agreed to participate in this study by signing the Biocollection consent form. * No known infectious pathology * No known history of cancer * No known history of chronic autoimmune disease * No background immuno-suppressive treatment Ancillary Study : -Metastatic NSCLC with a KRAS G12C mutation, receiving treatment with Sotorasib, Adagrasib, or another KRAS G12C inhibitor, either as monotherapy or in combination. Exclusion Criteria: Patients : * Previous anticancer treatment for Lung cancer * Patients who have not consented to participate in the BREATHE collection * History of cancer (excluding thoracic cancer) with evidence of disease for less than 2 years * Inclusion in a therapeutic trial with blinded treatment * Patients under guardianship * Patients with AME. * Pregnant or breast-feeding women Healthy subjects : * Person under guardianship * Person benefiting from AME (State medical aid) * Pregnant or breast-feeding women Ancillary Study : \- Pregnant or breast-feeding women
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What it tests

  • Blood Sampling (2*8mL Tubes)
  • PBMC Sampling (1*8mL Tubes)
  • Paxgene Sampling
  • Extended biopsies of tumor lesions
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Where

4 sites
CHU d'Angers
Angers, France
CHU Nantes
Nantes, France
CHU Rennes
Rennes, France
CHU Tours
Tours, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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