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Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation

RecruitingNAAges 18 Years - 70 YearsAllUniversitaire Ziekenhuizen KU Leuven
NCT06482138 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10 * Control group: No OD (TDI-score \>30.5.) Exclusion Criteria: * Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations * Use of anticoagulation therapy * Allergy to local anesthetics
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What it tests

  • Biopsy and Cytobrush
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Where

7 sites
Cliniques Universitaires Saint-Luc
Brussels, Belgium
UZ/KU Leuven
Leuven, Belgium
AZ Sint-Jan Brugge
Bruges, Belgium
University Hospital Carl Gustav Carus
Dresden, Germany
Max Planck Research Unit for Neurogenetics
Frankfurt am Main, Germany
Hôpitaux Universitaires de Genève
Geneva, Switzerland
University of Zurich and University Hospital Zurich
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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