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Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Toulouse
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In plain words

What the trial is, and whether it could suit you

The TOTEM study is a single-center study designed to evaluate the performance of the D-lactate assay in cerebrospinal fluid (CSF) for the diagnosis of ventriculostomy-related nosocomial meningitis. The study will be conducted in the neurosurgical intensive care unit of the Toulouse University Hospital, in patients with a suspected diagnosis of ventriculostomy-related nosocomial meningitis.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age โฉพ 18 years. * Patient with an external ventriculostomy implanted at the Toulouse University Hospital. * Patient suspected of nosocomial meningitis due to a febrile syndrome (in the absence of any other identified infectious site), headache, nausea, lethargy, change in neurological status, meningeal syndrome, epileptic event and cutaneous or subcutaneous inflammation at the ventriculostomy site of insertion. * Patient having expressed oral consent, after free and informed information. * Patient affiliated to a social security scheme. Exclusion Criteria: * Diagnosis of community meningitis. * Proven or suspected meningitis and/or ventriculitis during the previous month. * Diagnosis of nosocomial meningitis made in another medical centre prior to admission. * Short bowel syndrome. * Acute mesenteric ischaemia. * End-stage renal failure (GFR \< 15 ml/min/m2). * Peritoneal dialysis. * Patient participating in another research protocol with an exclusion period still in progress. * Pregnant or breastfeeding woman. * Patient under guardianship or trusteeship, persons placed under the protection of justice
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What it tests

  • CSF sample
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Where

1 site
Toulouse Hospital
Toulouse, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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