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Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

RecruitingPhase 2Ages 18 Years - anyAllUniversity of Maryland, Baltimore
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In plain words

What the trial is, and whether it could suit you

Cancer-related fatigue affects at least 30-90% of patients with cancer, depending on the type of cancer and their treatment(s) (e.g., chemotherapy, radiation). It is not relieved by sleep or rest, and it sometimes can persist for years after a person's cancer was treated. The fatigue can be so bad that people cannot return to work, hobbies, family roles, or other daily activities, thereby greatly reducing quality of life. The causes of this fatigue are unknown, and we currently do not have anything that can reliably prevent or cure the fatigue. However, there are recent data suggesting that circadian rhythm, or a person's internal body clock, may be disrupted by the cancer experience and contribute to fatigue. Food intake is an external cue that can entrain circadian rhythm. We recently showed that cancer survivors are willing and able to eat all their food within a 10-hour eating window

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria (Participants mustโ€ฆ): * Have a diagnosis of a hematologic neoplasm (e.g., leukemia, lymphoma, multiple myeloma); * Be at least 2 months post-treatment with chemotherapy, radiation, targeted therapy, chimeric antigen receptor (CAR)-T cell therapy, stem cell transplant, or another therapy (maintenance therapies are okay; steady unchanged treatment for relapsed disease for \>2 months and expected to stay on it until progression is okay); * Have a baseline level of fatigue, as determined by at least one of the following: 1. Reporting a score of 4 or higher in response to the question, "What was your worst fatigue in the last week, on a scale of 0-10, where 0 is no fatigue and 10 is the worst fatigue?" 2. In the habit of taking daytime naps, 3. Have fatigue that interferes with their ability to work, engage in social events, or is more than would be expected from physical exertion, * Be able to speak and/or read and write in English or Spanish; * Be at least 18 years old; and * Be able to provide informed consent. Exclusion criteria (participants must notโ€ฆ) * Be underweight, as defined as a body mass index \<18.5 kg/m2; * Already eat all their food within a window that is 10 h or shorter most (6/7) days of the week; * Be employed in a job where they regularly work away from the home at night (e.g., night shift); * Have surgery planned during the study duration; * Have any contraindications to the proposed nutrition intervention as identified by their medical provider, their designee, or the study team (e.g., type 1 diabetes, risk for hypoglycemia, medication requirements, pregnancy, breastfeeding, recent history of an eating disorder); * Be taking insulin; or * Be on enteral or parenteral nutrition.
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What it tests

  • Time-restricted eating
  • Nutrition counseling
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Where

1 site
University of Maryland, Baltimore
Baltimore, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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