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Enhanced MRI Imaging in Healthy Participants and Participants With Epilepsy

RecruitingPhase 2Ages 18 Years - 64 YearsAllUniversity of Alberta
NCT06483061 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Temporal lobe epilepsy (TLE) is a common type of epilepsy and one of the most likely to not be controlled by medication. For patients who do not respond to medication, surgery can result in a cure of seizures. Given the fact that around 50% of patients who undergo surgery are seizure free at 10 years there is a need to improve the understanding of what factors best predict surgical outcomes in order to improve our ability to select candidates for surgery. The demonstration of abnormalities in the temporal lobe on MRI is one of the best predictors of seizure free surgical outcomes. Recent studies suggest that changes in specific subregions of the hippocampus could be the strongest predictors of surgical success, however the small size of these regions, (millimeters) make them very difficult to study with standard clinical MRI. Recently new MRI methods have been developed at Wayne State

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy controls aged 18-64. * Patients with temporal lobe epilepsy aged 18-64 and hippocampal sclerosis demonstrated on clinical MRI scan Exclusion Criteria: * Non-English speaking participants will be excluded as we cannot provide translation services. * Inability to provide informed consent. * Contraindications to MRI Age \< 17 years / \>65 years * Weight \> 127.5kg (which is the maximum weight of which a single 510mg vial of Ferumoxytol would accommodate a 4mg/kg dose). * Women of childbearing capacity with a positive pregnancy test * Women who are actively breast feeding * Contraindication of Ferumoxytol -known hypersensitivity to Feraheme or any of its components -History of allergic reaction to any intravenous iron product
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What it tests

  • Ferumoxytol
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Where

1 site
Peter S. Allen MRI Unit
Edmonton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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