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Human Albumin Infusion in Liver Cirrhosis and Overt Hepatic Encephalopathy (HACHE)

RecruitingNAAges 18 Years - anyAllGeneral Hospital of Shenyang Military Region
NCT06483737 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hepatic encephalopathy (HE), a severe complication of decompensated cirrhosis, is characterized as neurocognitive dysfunction. Emerging evidence suggests the potential role of human albumin infusion for the treatment of HE, but its optimal dosage remains undefined. Therefore, the investigators planned a randomized controlled trial (RCT) to compare the efficacy of human albumin infusion at different dosages in in patients with liver cirrhosis and overt HE.

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📋 Eligibility rules (as published)
Inclusion Criteria: * A definite diagnosis of liver cirrhosis and overt HE * A serum albumin level of 23-30g/L * Age ≥18 years old * Sign the informed consent Exclusion Criteria: * Contraindications to human albumin infusion * A history of transjugular intrahepatic portosystemic shunt * A diagnosis of acute liver failure * Severe heart and/or lung diseases * Psychiatric or nervous diseases * Pregnant or lactating
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What it tests

  • Human albumin infusion at a modified dosage
  • Human albumin infusion at a routine dosage
  • Lactulose
  • Rifaximin
  • Ornithine Aspartate
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Where

1 site
Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area)
Shenyang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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