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Deciphering the Interactions Between Food Intake, Sleepiness, and Nighttime Sleep Quality in Patients With Type 1 Narcolepsy and Idiopathic Hypersomnia

RecruitingNAAges 18 Years - 65 YearsAllHospices Civils de Lyon
NCT06484348 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Links between sleep and food intake are manyfold. In healthy individuals, sleep deprivation promotes obesity by stimulating food intake of high glycemic index (GI) foods. Conversely, high GI foods induce sleepiness. Obesity is observed in 30-50% of patients with Narcolepsy type 1 (NT1). Its determinism may involve transient changes in basal metabolism at the early stage of the disease, eating disorders, disrupted nighttime sleep and sleepiness. In contrast, patients suffering from idiopathic hypersomnia (IH), whose nocturnal sleep is generally long and of good quality, rarely present with obesity. By studying the relationships between diet, body composition and sleep patterns in these two populations and in healthy controls, the NARCOFOOD study aims to provide a better understanding of the determinants of obesity in narcolepsy and, more generally, of the effects of food intake on sleepin

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📋 Eligibility rules (as published)
Inclusion Criteria : * Patients with NT1 or IH (ICSD-3-TR) or Healthy Controls without sleep disorder * Familiar use of a smartphone Exclusion Criteria : * Untreated moderate or severe sleep apnea syndrome; * Cognitive disorders incompatible with the protocol; * Unstable treatment or treatment with sodium oxybate; * Unstable medical or psychiatric pathology; * Shift work; * Pregnancy or breastfeeding; * Diabetes
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What it tests

  • Monitoring of eating behaviors
  • Monitoring of sleep/wake rhythm
  • Measure of nocturnal sleep parameters
  • Measure of sleepiness
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Where

2 sites
Unité de Neurophysiologie-sommeil, Département de Neurologie, CHU de Clermont-Ferrand
Clermont-Ferrand, France
Center for Sleep Medicine, Hospices Civils de Lyon
Lyon, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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