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Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

RecruitingPhase 2Ages 18 Years - 79 YearsFemaleUnited States Naval Medical Center, Portsmouth
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia. Exclusion Criteria: * Pregnant, * Patients with gastrointestinal disease requiring ongoing medical management. * Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy. * Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery. * Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis. * Known r suspected malignancy * Lactose intolerance
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What it tests

  • pantoprazole
  • Placebo
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Where

1 site
Naval Medical Center Portsmouth
Portsmouth, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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