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Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment

RecruitingNAAges 65 Years - anyAllShanghai 10th People's Hospital
NCT06488807 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear. Our previous clinical studies demonstrated the association between olfactory impairment and PND. Moreover, our translational studies showed that anesthesia/surgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia/surgery-induced cognitive impairment. However, there was no clinical investigation to determine whether olfactory enrichment can mitigate PND in elderly patients. Therefore, we propose determining whether olfactory enrichment can prevent and/or treat PND in elderly patients.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥65 years old. 2. Having a scheduled surgery (≥2 hours, general anesthesia) (e.g., total hip replacement, toal knee replacement, open reduction and internal fixation of hip and lumbar spine). 3. Being able to complete neuropsychological tests, 3D-CAM and CAM-S. 4. Chinese Mandarin as their native language. 5. Edmonton frailty scale (EFS) score ≥ 6. Exclusion Criteria: 1. Having delirium, assessed by 3D-CAM, before surgery. 2. Having a brain tumour, stroke or mental disorders (eg, major depressive disorder or dementia). 3. Participating in other clinical studies at the time of screening. 4. Unwillingness to comply with the protocol or procedures.
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What it tests

  • Olfactory Enrichment
  • Sham
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Where

1 site
Shanghai Tenth People's Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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