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Diagnostic of Various Ototoxicity Induced by Cancer Treatment

Recruitingn/aAges 18 Years - anyAllDirection Centrale du Service de Santé des Armées
NCT06490029 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

• Visit the clinic once every 2 weeks for checkups and tests The goal of this clinical trial is to learn if systematic hearing tests (eg fonctional assesment, electrophysiology and seric biomarkers) can diagnose hidden hearing loss or vestibular troubles in a population of patients treated for cancer; population study will include different population in terms of sex/gender, age, medical condition (cancer patients treated with surgery alone and/or radiotherapy and/or chemotherapy, and healthy volunteers). The main question it aims to answer is: • To assess the ototoxicity of anticancer drugs using a combination of auditory functional tests (including speech audiometry in noise), vestibular test , plasmatic samples and electrophysiological measures. Participants will be studied: Either only after exposition (single visit) Or before, during and after the exposition to potential otototo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 and over * Registered with social security * Signed consents * Absence of presbycusis prior to cancer treatment (groups A and C) * No known presbycusis (group B) * Previous exposure to an ototoxic/neurotoxic agent (group A) * Indication for initiation of ototoxic/neurotoxic therapy (group C) Exclusion Criteria: * \- Subjects deprived of liberty * Subjects unable to read or write the French language * Pregnant and breast-feeding women * Previous treatment for ototoxicity * History of bilateral auditory pathology, in particular otosclerosis, perilymphatic fistula, ruptured tympanic membrane, autoimmune hearing loss, acoustic neuroma. * History of severe head trauma (Glasgow Coma Score \<= 8) * Abnormal otoscopy or tympanometry In addition for group B * Previous chemotherapy * Previous ENT radiotherapy * Ongoing ototoxic drug therapy (quinine, diuretics, aminoglycosides, aspirin, NSAIDs) or corticosteroid therapy
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What it tests

  • Auditory, vestibular and electrophysiological investigations
  • Biologic investigations; seric proteins
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Where

1 site
HIA Bégin
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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