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Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia

RecruitingPhase 2Ages 8 Years - 35 YearsAllNational Institute of Blood and Marrow Transplant…
NCT06490627 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The project "Unraveling the Impact of Thalidomide at Diverse Doses in Transfusion Dependent Beta Thalassemia" investigates the safety and efficacy of low-dose thalidomide in managing beta thalassemia, a genetic disorder causing anemia. Conducted over two years at NIBD hospital, the study involves 54 transfusion-dependent patients aged 8-35. The primary objective is to correlate thalidomide doses with disease severity, adverse effects, and treatment response, aiming to optimize treatment strategies and reduce side effects. Data will be collected through clinical interviews and medical record reviews and analyzed using SPSS. Key variables include hemoglobin levels, leukocyte and reticulocyte counts, platelets, liver and spleen size, genetic modifiers, and transfusion frequency. Inclusion criteria are specific to beta thalassemia patients, while exclusion criteria rule out those with liver

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📋 Eligibility rules (as published)
Inclusion Criteria: * Know case of beta thalassemia major/ intermediate ( transfusion dependent) * willing to give informed consent Exclusion Criteria: * Patients with comorbidities such as liver dysfunction * Married patients * Lactating mother * H/O thrombosis and fits
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What it tests

  • Thalidomide
  • Thalidomide
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Where

1 site
National Institute of blood disease and bone marrow transplant
Karachi, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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