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Comparing Approaches to Assess Nitric Oxide-dependent Cutaneous Vasodilation

RecruitingEARLY Phase 1Ages 18 Years - 30 YearsAllUniversity of Iowa
NCT06499844 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The increase in skin blood flow in response to rapid local heating of the skin (i.e., cutaneous vasodilation) is commonly used to assess nitric oxide (NO)-dependent dilation and overall microvascular function. Historically, rapid local heating to 42°C was considered the standard approach for these assessments. More recently, many investigators have adopted rapid local to 39°C instead, based on its larger dependency on NO and therefore improved ability to quantify NO-dependent dilation without the use of pharmacological techniques. However, to date, only one direct methodological comparison between these protocols has been performed. In this study, the investigators use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. Using a minimally invasive technique (intradermal microdialysis for the local delivery of pha

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📋 Eligibility rules (as published)
Inclusion Criteria: * men and women * 18-30 years of age Exclusion Criteria: * Current or recent (within 8 wks) use of medication that could conceivably alter microvascular function \[including (but not limited to) stimulants, antihypertensives, HMG-CoA reductase inhibitors\] * Changes or alterations in medication status (starting a new, additional, or different medication or changing the dose of a current medication) * Unstable or diagnosed chronic clinical disease, including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological disease (e.g., hypertension, heart disease, diabetes, hyperlipidemia, psoriasis) * Body mass index \<18.5 or \>35 kg/m2 * Pregnancy (including a positive urine pregnancy test) or breast-feeding * Known allergies to pharmacological agents or study drugs * Non-English-speaking. Participants need to understand English to follow instructions and comply with procedures conducted during the screening and experimental visits.
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What it tests

  • Acetylcholine
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Where

1 site
University of Iowa
Iowa City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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