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Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations

RecruitingNAAges 18 Years - 50 YearsAllCentre Hospitalier Universitaire, Amiens
NCT06502431 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A global analysis of craniospinal hemodynamics and hydrodynamics is necessary to better understand the pathophysiology of Chiari malformations. This includes an analysis of intraventricular CSF flow, intracranial subarachnoid spaces, foramen magnum, cervical subarachnoid spaces and within the syringomyelia cavity when present. The investigators will also analyze the pulsatility of the cerebellar tonsils in the foramen magnum. Hemodynamic analysis will be performed at the high cervical level (internal carotid and vertebral arteries, jugular veins) and intracranially (carotid and basilar arteries, right sinus and superior longitudinal sinus). This analysis will be made possible by PCMRI acquisitions with slice planes allowing the analysis of the dynamics of the CSF (mesencephalic aqueduct, prepontic cisterns, foramen magnum, at the level of the C2C3 disc, syringomyelia if present), cerebel

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📋 Eligibility rules (as published)
Inclusion Criteria: * All patients with major symptomatic or nonsymptomatic CMI * aged 18 to 50 years * no previous neurosurgical, neurological, or cardiological history. * Controls should be age-matched to symptomatic CMI group. They should not have a history of neurosurgery, neurology, or cardiology. Exclusion Criteria: * Patients who are minors or over 50 years of age * CMI invalidated by our radiological review * Neurosurgical, neurological or cardiological history * MRI contraindication * pregnant, breast-feeding and parturient women
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What it tests

  • phase contrast sequences
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Where

1 site
CHU Amiens Picardie
Amiens, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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