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Targeting the Skeletal Muscle to Treat Metabolic Dysfunction-associated Steatotic Liver Disease

RecruitingNAAges 18 Years - 70 YearsAllCliniques universitaires Saint-Luc- Université Ca…
NCT06506513 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Muscle changes including myosteatosis are reported as highly prevalent in metabolic dysfunction-associated steatotic liver disease (MASLD). Recent studies highlighted a link between muscle fat content and liver disease severity. Conversely, MASLD histological remission though diet or metabolic surgeries is also linked to a decrease in muscle fat content. Therefore, skeletal muscle appears as a potential target to treat MASLD.

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📋 Eligibility rules (as published)
Inclusion Criteria: * confirmed MASLD at abdominal imaging * confirmed excessive muscle lipid content at imaging * stable weight Exclusion Criteria: * severe comorbidities including active malignancies, neuromuscular degenerative diseases * contraindications to physical activity * excessive alcohol consumption
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What it tests

  • High-intensity interval training
  • Moderate intensity exercise training
  • Low intensity exercise training
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Where

2 sites
Cliniques universitaires Saint-Luc
Brussels, Belgium
Centre d'investigation clinique en nutrition
Louvain-la-Neuve, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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