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Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction

RecruitingNAAges 18 Years - anyAllRomanian Society for Enteral and Parenteral Nutri…
NCT06510348 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Clear study hypothesis / research question It has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality. Although it was thought that achivieng optimal delivery of calories will prevent nutritional deficits in critically ill patients, published randomized controlled trials failed to confirm this hypothesis. Combinging enteral and parenteral support may be an efficent strategy to reach nutritional target in critically ill patients. According to the current guidelines the use of suplemental parenteral nutrition (SPN) should be considered when energy targets are not achieved by enteral (EN) route, however, no clear data regarding timing, amount and composition is specified. Moreover, based on recente published data overfeeding should also be avoided, considering the negative impact on outcome. Nutritional suppo

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📋 Eligibility rules (as published)
Inclusion Criteria: * All adults (\> 18 years old) * Mechanical ventilation for more than four days, * Controlled shock state (hemodynamic and tissue perfusion goals are reached) - Impaired intestinal absorbtion, defiend by both ultrasound measurement of gastric residual volume and paracetamol absorbtion test Exclusion Criteria: * patients on non-invasive mechanichal ventilation * contraindication for EN for \> 48 h after admission * patients with gastrointestinal surgical intervention within 3 months, * history of malabsorption, inflammatory bowel disease * short bowel syndrom * anorexia nervosa * gastrointestinal bleeding * cirrhosis * traumatic brain injury * subarahnoidal hemorrhage * neoplasia * post cardiac arrest patients * patients on chronic therapy with corticosteroids * pregnant women.
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What it tests

  • Supplemental Parenteral Nutrition (SPN)
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Where

1 site
Clinical Emergency Hospital of Bucharest
Bucharest, Romania
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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