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Isometric Resistance Exercise for Hypertension

RecruitingNAAges 18 Years - anyAllChinese University of Hong Kong
NCT06510998 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Isometric resistance exercises (IREs) have great potential to improve blood pressure (BP) control. However, the effectiveness of IREs in reducing HT is still unknown because their hypotensive effects have not been detected using ambulatory BP measurements (ABPM), which are the current standard for BP measurement. Methods: This first adequately-powered RCT will involve 390 patients with HT who do not meet the current physical activity guidelines defined by the World Health Organization. Participants will be randomly assigned in a 1:1 ratio using stratified and blocked randomization to either the IRE (wall squat) group or stretching exercise (active control) group. A well-structured, widely accepted, and validated 24-week wall squat program (2 minutes per exercise, 2 minutes of rest between sets, and 3 sessions per week) will be implemented, as it has been commonly used in pre

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📋 Eligibility rules (as published)
Inclusion Criteria: * a suboptimal daytime SBP of \>135-160 mmHg on a 24-h ABPM * reported no regular physical activity or less than that recommended for adults by the World Health Organization (e.g. \<150 minutes of moderate-intensity aerobic exercise per week) * on stable doses of anti-HT medication(s) for ≥4 weeks if the patient is receiving drug treatments; * agree for no drug changes during the intervention period (24 weeks); Exclusion Criteria: * cannot provide informed consent * unwillingness to repeat ABPM * relative contraindications to ABPM (i.e. diagnosed atrial fibrillation, nighttime workers, occupational drivers, or patients with bleeding tendencies) * severe osteoarthritis pending knee replacement surgery * known secondary HT * use of ≥3 anti-HT medications at maximum doses or ≥4 anti-HT medications * SBP or DBP are \>160 mmHg or \>100 mmHg, respectively, on ABPM at baseline or at 12 weeks follow-up to ensure safety * pregnancy/breastfeeding * active malignancy
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What it tests

  • isometric wall exercise
  • passive stretching
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Where

2 sites
Lek Yuen General Outpatient Clinic
Hong Kong, Hong Kong
School of public health and primary care
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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