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Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest

Recruitingn/aAges 18 Years - anyAllByron Drumheller
NCT06511999 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients successfully resuscitated from sudden cardiac arrest are often comatose, having suffered a period of low blood flow and oxygen delivery to the brain. They are also at risk of suffering further brain injury during the immediate period after resuscitation, in which the brain's normal regulatory functions are impaired. To diagnose and treat secondary brain injury in comatose patients after cardiac arrest, doctors use a variety of neurological monitoring techniques. One of these methods involves measuring the oxygen saturation of blood going into and out of the brain to determine whether the brain is receiving and utilizing oxygen in an optimal manner. The oxygen saturation of blood exiting the brain is called the jugular venous oxygen saturation (SjO2). It is measured by inserting a catheter into the jugular vein in the neck and sampling blood as it exits the skull. The blood sampl

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📋 Eligibility rules (as published)
Inclusion Criteria: • Adults (\>=18 years old) resuscitated from out-of-hospital or in-hospital cardiac arrest who remain comatose (motor Glasgow coma scale \<=4) for at least 30 minutes when examined off sedation/neuromuscular blockade. Exclusion Criteria: * Cardiac arrest due to traumatic brain injury, intracranial bleeding, or ischemic stroke * Cervical spine fracture * Need for immediate prone positioning for severe hypoxemic respiratory failure * Marked hemodynamic instability precluding priority of any neuromonitoring (multiple recurrent cardiac arrests, norepinephrine equivalents \> 1.5 mcg/kg/min) * Moribund neurological status based upon initial clinical, radiographic and historical assessment (e.g. diffuse cerebral edema or herniation on head computed tomography) * Pregnancy * Prisoners
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What it tests

  • Continuous SjO2 monitoring with a PediaSat Oximetry Catheter
  • Intermittent SjO2 monitoring with a PediaSat Oximetry Catheter
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Where

1 site
UPMC Presbyterian Hospital
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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