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Uterine Preservation in the Management of Placenta Accreta Spectrum Disorders

RecruitingNAAges 18 Years - anyFemaleUniversity of Pennsylvania
NCT06512181 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study for the conservative management of placenta accreta spectrum disorders (PAS), which are a major cause of maternal morbidity and mortality. The most common management strategy for PAS in the United States is a preterm cesarean-hysterectomy. However, accumulating data show that conservative management is safer and is preferred by some patients. In selected participants (n=15) who desire uterine preservation, the investigators provide the option of conservative management, which will be defined as leaving the placenta in the uterus after delivery of the infant. This is a single-arm single-site pilot study where all participants will be carefully monitored during a standard postpartum inpatient stay and with outpatient follow-up until the uterus is empty.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Provision of signed and dated informed consent form. 2. Stated willingness to comply with all study procedures and availability for the duration of the study. 3. A person with a uterus, age 18 or older 4. Currently pregnant with an intrauterine gestation or postpartum 5. Suspected of having PAS based on history, clinical findings, and/or imaging 6. Patients for whom the usual management would be peripartum hysterectomy. 7. Patient desires uterine preservation or declines hysterectomy 8. Agreement to adhere to Lifestyle Considerations (see section 5.3) throughout study duration. Exclusion Criteria: • Have a low antenatal suspicion for PAS based on imaging.
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What it tests

  • Conservative/Expectant Management
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Where

1 site
Hospital of the University of Pennsylvania
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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