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Can Near-Infrared Spectroscopy (NIRS) or Intramuscular Glucose Levels Detect Impaired Leg Compartment' Perfusion?

Recruitingn/aAges 18 Years - 75 YearsAllUniversity of Florida
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In plain words

What the trial is, and whether it could suit you

Near infrared spectroscopy (NIRS), a technique that relies on differential absorption of infrared light to provide relative estimation of tissue oxygenation, has been successfully used to monitor perfusion of various tissues, including muscle tissue of the lower extremity, however available research reports mixed success and this technology is not currently a standard of care for patients with leg fractures. The investigators propose use of NIRS technology in patients with diagnosis of tibial fracture and acute compartment syndrome to detect / document impaired perfusion of the anterior compartment of the leg, as compared to their non-broken leg. The investigators also propose measurement of intramuscular glucose level in the affected leg and compare it to a fingerstick glucose to detect relative hypoglycemia in the affected muscular compartment. If proven effective, NIRS, or IM glucose

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. 18 years of age to 75 years of age 2. Diagnosis of tibial fracture or fracture-dislocation complicated by diagnosis of acute compartment syndrome AND/OR diagnosis of concomitant vascular injury with documented loss of pulses in the leg below the knee 3. Unilateral injury (i.e. only one leg is affected) 5\) Depth of anterior compartment of the leg \< 2.5 cm (as measured by ultrasound) 6) Willing to consent to the study Exclusion Criteria: 1. Younger than 18 years of age or over 75 years of age 2. Skin damage, open wound or infection at the skin overlying the anterior muscular compartment, preventing NIRS sensor placement. 3. Depth to the muscle more than 3 cm as assessed with ultrasound. 4. History of fasciotomy performed on the affected leg. 5. Inability to obtain the informed consent from the patient of legal guardian or healthcare surrogate. 6. Language barrier- Inability to read or understand spoken English
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What it tests

  • Near infrared spectroscopy (NIRS)
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Where

1 site
UF Health
Gainesville, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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