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โ† Trials
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A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)

RecruitingPhase 2Ages 6 Months - anyAllAllotera Therapeutics
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In plain words

What the trial is, and whether it could suit you

The T-RRex study evaluates the efficacy of WU-CART-007 for patients with Relapsed/Refractory (R/R) T-Cell Acute Lymphoblastic Leukemia (T-ALL)/Lymphoblastic Lymphoma (LBL) and to WU-CART-007 as a therapy to induce complete Minimum Residual Disease (MRD) negative response

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Key Inclusion Criteria: * Disease Criteria: Evidence of T-ALL or T-LBL, as defined by World Health Organization (WHO) classification, and either relapse/refractory or MRD positive * Age: Lower age limit of โ‰ฅ 6 months; adequate organ function * Eastern Cooperative Oncology Group (ECOG) 0 or 1/Karnofsky Performance Status 70 and above at Screening. Key Exclusion Criteria: * Prior treatment with any anti-CD7 therapy. * Patients with decompensated hemolytic anemia. * Presence of Grade 2 to 4 acute or extensive chronic GvHD requiring systemic immunosuppression. Grade 1 GvHD not requiring immunosuppression or Grade 2 skin GvHD if treated with topical therapy only are acceptable.
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What it tests

  • WU-CART-007
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Where

18 sites
City of Hope
Duarte, United States
Children's Hospital Los Angeles
Los Angeles, United States
Colorado Blood Cancer Institute
Denver, United States
Children's National Hospital
Washington D.C., United States
H. Lee Moffitt Cancer Center and Research Institute Hospital
Tampa, United States
Children's Hospital of Atlanta
Atlanta, United States
Washington University Saint Louis
St Louis, United States
Memorial Sloan Kettering Cancer Center -- Pediatrics
New York, United States

โ€ฆand 10 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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