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Emotion and Memory in Chronic Neuropathic Pain

Recruitingn/aAges 35 Years - 60 YearsAllUniversity Health Network, Toronto
NCT06518421 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic pain affects one in four Canadians, leading to severe personal and societal costs. Over 70% of chronic pain patients report memory difficulties and fear having unexpected pain. Abnormalities in brain structures associated with emotion and memory, including the hippocampus and amygdala, can be affected by chronic pain. Understanding the relationship between chronic pain, structural brain changes, and cognitive functioning will lead to improved diagnosis, treatment, and outcomes in chronic pain disorders. In this project, the investigators will use advanced brain imaging techniques that assess the structure and function of the brain along with cognitive assessments to examine the overlap between chronic pain and emotion-memory processes. The study team will conduct the study using an excellent model of chronic pain-trigeminal neuralgia, a severe form of facial pain that responds we

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📋 Eligibility rules (as published)
Inclusion Criteria (for HC and TN): * Age between 35 and 60 years old * Absence of other active major neurological or psychiatric disorders * Absence of MRI contraindications * Able to communicate sufficiently to complete tasks and questionnaires * Montreal Cognitive Assessment (MoCA) score greater than 23/30 (MoCA ≤23/30 could indicate severe cognitive impairment) Inclusion Criteria for TN: * Experiencing TN pain over a period of 6 months * Stable medication use * Meet established diagnostic criteria for TN (ICHD-3) Exclusion Criteria (both HC and TN): * Presence of other chronic pain/headache conditions * Untreated hypertension or diabetes mellitus * History of chronic drug or substance use disorder, chronic use of opioids or steroids, head trauma affecting cognitive performance, * History/presence of active psychiatric illness and/or current use of psychoactive medication * History of multiple sclerosis, skull base injury or tumours
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What it tests

  • Neuropsychological assessments
  • MR Imaging
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Where

1 site
Toronto Western Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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