AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia

RecruitingPhase 4Ages 0 Days - 12 MonthsAllUniversity of Alabama at Birmingham
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if caffeine citrate prevents apneic events that result in sick visits in moderately preterm infants after discharge from the hospital. It will also learn if the use of caffeine leads to better developmental outcomes at 12 months of age. Our research questions are: 1. Does continued treatment of moderately preterm newborns with caffeine citrate after hospital discharge prevent or decrease apneic events that result in sick visits? 2. Will the continued use of caffeine citrate lead to improved developmental outcomes among infants at 12 months of age? Researchers will compare caffeine citrate to a placebo (a look-alike substance that contains no drug) to see if caffeine citrate prevents apneic spells which result in healthcare visits. Parents of participants will: 1. Administer caffeine citrate 20mg/kg/day or a placebo (equivalent volume of st

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: Newborns: 1. 29 0/7 to 33 6/7 weeks GA (or with a birth weight 1.0 to 2.0 kg if pregnancy dating is unreliable) admitted to the UTH NICU, 2. On methylxanthines with plans to discontinue on methylxanthine, 3. Off oxygen therapy for \>48 hours at the time of evaluation for eligibility, 4. Receiving full daily feeds, 5. Deemed stable and ready to go off caffeine as recommended by the Neonatologist 6. 18+ years of age (parent) Exclusion Criteria: 1. Newborns with neuromuscular conditions affecting respiration, 2. Major congenital malformations and genetic disorders, 3. Unable to obtain parental or guardian consent
๐Ÿ’Š

What it tests

  • Caffeine citrate 20mg/kg/day
  • Placebo-Sterile water 1ml/kg/day
๐Ÿ“

Where

1 site
University Teaching Hospital
Lusaka, Zambia
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy