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Environmental Exposure to Heavy Metals, Nanoparticles, and Emergent Contaminants and Risk of Allergic Diseases

RecruitingNAAges 18 Years - anyAllFondazione Policlinico Universitario Agostino Gem…
NCT06529913 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to collect environmental, bio-humoral, and clinical data derived from patients with allergic contact dermatitis (ACD) and systemic metal allergic syndromes related to the exposure to heavy metals, nanoparticles, and emergent contaminants and from healthy subjects. The main question it aims to answer is: are environmental, bio-humoral, and clinical data derived from patients with ACD and systemic metal allergic syndromes, related to the exposure to heavy metals, nanoparticles, and emergent contaminants, different from ones obtained by healthy subjects? Researchers will compare serum and urine concentration of heavy metals and nanoparticles, patch test to metals, within-breath analysis of oscillometry parameters, serum zonulin, and serum levels of protein oxidation products among patients with systemic allergic syndrome (1st study group), patients with A

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📋 Eligibility rules (as published)
Inclusion Criteria: * adult subjects (over 18 years of age). * Subjects suffering from allergic contact dermatitis due to metals. * Subjects with systemic allergic syndrome due to metals. * Adult healthy subjects. * Subjects able to give written informed consent. Exclusion Criteria: * Subjects under the age of 18years. * Pregnant/breastfeeding women. * Subjects suffering from chronic renal failure requiring replacement treatment. * Subjects suffering from other systemic pathologies related to exposure to metals. * Subjects suffering from gastrointestinal diseases such as celiac disease, chronic inflammatory intestinal diseases, tumors, other skin diseases. * Subjects unable to express written informed consent.
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What it tests

  • Collection of environmental, biological, and clinical data
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Where

2 sites
Università di Bologna
Bologna, Italy
Fondazione Policlinico Universitario A. Gemelli IRCCS
Roma, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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