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โ† Trials
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Abbreviated MRI Using Gadoxetic Acid Versus CT for Surveillance of Recurrent HCC After Curative Treatment

RecruitingNAAges 20 Years - anyAllAsan Medical Center
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In plain words

What the trial is, and whether it could suit you

Hepatocellular carcinoma (HCC) often has a poor prognosis after curative treatment due to frequent recurrence. Post-surgery, 60-70% of HCC patients experience recurrence, rising to 80% after ablation therapy. This is partly because underlying cirrhosis or chronic liver disease remains, increasing the risk of secondary HCC. The risk of recurrence varies over time, with a high risk in the first two years due to micro-metastasis. Later recurrences are usually new primary cancers (de novo HCC). Therefore, regular imaging tests, such as computed tomography (CT) or magnetic resonance imaging (MRI) every three months in the first two years, are necessary for early detection, but guidelines for post-two-year screenings are unclear. Currently, for patients recurrence-free for two years, contrast-enhanced liver CT or MRI is performed every 3-6 months as a secondary screening test. However, repeat

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patients with more than two years without recurrence after curative treatment (surgery or local ablation) for HCC 2. Patients with no history of systemic treatment, radiation therapy, or trans-arterial chemoembolization for HCC 3. Older than 20 years of age 4. Eastern Cooperative Oncology Group performance status of 0-2 5. Patient is able to comply with scheduled visits, evaluation plans, and other study procedures 6. Patient is willing to provide written informed consent Exclusion Criteria: 1. Active or suspected cancer, or a history of malignancy where the risk of recurrence is equal or higher than 20% within 2 years. 2. Significant medical comorbidities in which survival is predicted to be less than 3 years 3. Estimated glomerular filtration rate \< 30 mL/min/1.73mยฒ 4. Child-Pugh class C 5. Patient not eligible for applying LI-RADS criteria, such as Budd-Chiari Syndrome 6. Previous history of severe allergic reaction to iodine contrast medium 7. Precautions for MRI (cardiac pacemaker, severe claustrophobia that may interfere with protocol compliance). 8. Any other condition which, in the opinion of the Investigator, would make the patient unsuitable for enrollment or could interfere with completing the study.
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What it tests

  • AMRI
  • CT
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Where

1 site
Asan Medical Center
Seoul, South Korea
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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