💬In plain words
What the trial is, and whether it could suit you
Healthy ageing is associated with the loss of muscle mass and physical function. As a result, older people are limited in their independence. The aging of muscles typically begins around the age of 30. From this age onward, muscle strength, muscle mass, and the maximum oxygen uptake of muscles decrease. The reasons for this are not entirely clear, but it seems to be partly related to how oxygen moves from our blood vessels to the muscles and how muscles burn energy. The precise role of age and physical fitness, as well as whether exercise can counteract the effects of ageing, is still unknown. Therefore, in this study, we aim to investigate the muscle function of both physically active and inactive young and middle-aged individuals. We hypothesise that endurance training can mitigate some of the effects of ageing.
Sign in to get the eligibility rules as simple questions to take to your doctor.
📋 Eligibility rules (as published)
Inclusion Criteria:
In order to be eligible to participate in this study, young sedentary participants must meet all of the following criteria:
* Aged between 18-30 years
* Male or female
* Not currently engaging in any formal exercise training or competitive sports
* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
In order to be eligible to participate in this study, young trained participants must meet all of the following criteria:
* Aged between 18-30 years
* Male or female
* Currently engaging in formal training (at least 3 times per week) in competitive endurance sports
* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
In order to be eligible to participate in this study, older sedentary participants must meet all of the following criteria:
* Aged between 50-65 years
* Male or female
* Not currently engaging in any formal exercise training or competitive sports
* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
In order to be eligible to participate in this study, older trained participants must meet all of the following criteria:
* Aged between 50-65 years
* Male or female
* Currently engaging in formal training (at least 3 times per week) in competitive endurance sports
* No chronic health conditions likely to affect exercise tolerance or the physiological responses to exercise
Exclusion Criteria:
* Age that falls outside of 18-30 years (young groups) or 50-65 years (middle-aged groups)
* Inability to provide informed consent
* History of claustrophobia
* Ineligibility to perform the exercise test described in this study protocol or follow instructions
* Taking any medications known to interfere with the physiological responses to exercise, e.g. e.g. systemic corticosteroids, statins, SGLT2 inhibitors, GLP1 receptor agonists
* Contraindication for MRI (e.g. pacemaker, claustrophobia)
* Being under investigation for non-diagnosed disease at the time of investigation
* Body Mass Index (BMI) \>30 due to adiposity, since this is known to cause difficulties in obtaining muscle biopsies and NIRS measurements
* Pregnancy
* Are current smokers or have been a regular smoker within the last 12 months
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